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Presentation
Imagine Institute iPSC core facility
In July 2015, the Imagine Institute iPSC Core Facility was created. The iPSC platform allows the development of new cellular models for the study of rare diseases. The goals of the platform are three-fold:
- The generation and maintenance of iPS cells
- The characterization of iPS Cell lines
- Users training
The missions of the Platform are :
- Cellular reprogramming of human somatic cells from patients and healthy donors into iPS cells
- Expanding, maintaining, and banking of iPS cells
- Molecular and functional characterization of iPS cells
- Scientific and technical advice to users
- Assist users in the design of their project
Equipment
The iPSC platform is equipped with:
- Three incubators including 1 with tris-gas option for both hypoxic and hyperoxic studies
- Three class II biological safety cabinets
- Inverted microscope with phase contrast optics
- Two Lynx Dynascope under class II biological safety cabinet
- Celena™ S Digital Cell Imaging System
- Orbital shaker
- Centrifuge
- Ultra low temperature freezer (-150°C)
Team
Resources & publications
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Journal (source)Sci Rep
Urine-derived cells provide a readily accessible cell type for feeder-free mR...
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Journal (source)Elife
High N-glycan multiplicity is critical for neuronal adhesion and sensitizes t...
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Journal (source)Hum. Mol. Genet.
Early transcriptional changes linked to naturally occurring Huntington's dise...
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Journal (source)J. Clin. Invest.
Recurrent genomic instability of chromosome 1q in neural derivatives of human...
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Journal (source)Regen Med
Human embryonic stem cells and genomic instability.
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Journal (source)Nat. Biotechnol.
Human embryonic stem cells reveal recurrent genomic instability at 20q11.21.
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Journal (source)Proc. Natl. Acad. Sci. U.S.A.
Striatal progenitors derived from human ES cells mature into DARPP32 neurons ...